February Featured CHOP Postdoc


The February Featured CHOP Postdoc is Francis Ayombil, PhD. Francis is originally from Ghana, West Africa, but received his PhD in Biochemistry from the University of Vermont. Currently, Francis works under the mentorship of Rodney M. Camire, PhD.

At CHOP, Francis' research seeks to understand the molecular mechanisms regulating key aspects of the termination phase of blood clotting following a bleeding episode. One of his laboratory’s favorite proteins and one which he studies is called factor V, a protein molecule which participates in and sustains the propagation phase of blood coagulation following an injury. Forming a key element of a larger enzyme complex called prothrombinase, Francis’ research focuses on how the active form of factor V, factor Va, is down-regulated by activated protein C. In the near future, his research work will explore the structural determinants that both allow and promote the inactive state of factor V in quiescent blood prior to an injury.

In addition to Francis’ research, his biggest accomplishment thus far at CHOP has been receiving a young investigator award to be able to present his research in Berlin, Germany during the 2017 International Society of Thrombosis and Haemostasis (ISTH) Congress. Francis reflects on this accomplishment by saying, “Being arguably the biggest International Conference in my area of study, it was truly rewarding to get the opportunity to give a talk highlighting our findings observed here at CHOP (in the Camire Lab) at a big stage like the ISTH congress.”

Besides dedicating most of his time to research, Francis also finds time to enjoy his favorite TV show, Anderson Cooper 360. Although he is not a big novel reader, Francis likes to read trending news in the tabloids online.  Right now, Francis' favorite song to listen to is Love My Life by Demarco. To relieve stress, Francis will play and watch FIFA soccer games. If there was any place in the world he could go, Francis would travel to Liverpool, England.

When asked why Francis would like to connect or collaborate with other CHOP postdocs, he replied:

"[I would like to] understand and broaden my repertoire of experimental techniques and knowledge required to tackle the complexities of treating rare and unique pediatric bleeding disorders."