Postdoctoral Fellow positions are available in the Postdoctoral Fellowships Available in the Division of Pathology.

Description:
The Division of Cell Pathology within the Department of Pathology & Laboratory Medicine comprises a group of investigators with a shared interest in understanding the molecular and subcellular basis of human physiology and its relationship to heritable diseases. Most of the laboratories focus either in immunity or cancer biology, but extend into hemostasis and other physiological systems as well. The Post-doctoral Fellow will participate in one of three ongoing projects in the Marks laboratory that focus on membrane trafficking processes during the formation or maturation of tissue-specific lysosome related organelles. Our laboratory focuses on organelle maturation in pigment cells of the skin and eye, dendritic cells of the immune system, lung epithelial cells, and platelets/ megakaryocytes. Details of the project of focus will be determined in consultation with the Principal Investigator. Possible projects include:

  • 1. Dissection of mechanisms involved in the regulation of amyloid formation by the functional amyloid protein, PMEL, in pigment cells using cell culture or in vitro models.
  • 2. Analysis of pathology in transgenic mice expressing hypopigmentation-associated PMEL mutants in pigment cells or neuronal tissue.
  • 3. Assessing candidate proteins for localization to platelet dense granules, defining dense granule dynamics relative to endolysosomal organelles within platelets, and defining how localization and dynamics are impacted in genetic disease.
  • 4. Dissection of the molecular basis for autophagy sensitivity in cells from models of Hermansky-Pudlak syndrome.
  • Requirements:

  • Requires terminal degree PhD, MD, DVM, etc.
  • Strong research skills
  • Effective problem solving/critical thinking skills
  • Ability to work independently
  • Ability to exercise discretion and judgment
  • Value for research integrity and collaborative research
  • High level of motivation
  • Good communication skills
  • Strong interpersonal skills
  • Postdoctoral fellows at The Children's Hospital of Philadelphia receive mentored training in a rich scientific environment and conduct independent as well as collaborative research. Visit http://www.research.chop.edu for more information about The Children's Hospital of Philadelphia Research Institute and its research programs.

    Mandatory Requirements:

  • Child Abuse Clearances
  • FBI Fingerprint Clearance
  • Drug Screening
  • Tobacco screening
  • All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

    To apply, visit http://www.chop.edu/careers and search for Requisition #16-40212.

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